Abstract
A case of advanced osteosarcoma arising from the left maxilla was presented. The patient was a 32-year-old female who had undergone a surgery for benign osteoblastoma of the left maxilla 7 years previously. She had a remarkably large mass which covered all of the left face. The histopathological diagnosis of biopsy specimens was osteosarcoma. After high-dose methotrexate therapy and radiotherapy, the tumor was reduced in size. A reduction operation (tumor resection) was performed as the palliative treatment. The residual tumor had been stable after operation, but it metastasized to both the right upper lung and the right side of the brain thereafter. In spite of stereotactic multiple area radiotherapy performed on the right side of the brain, she died of respiratory failure. Autopsy revealed metastatic lesions in the right upper lobe of the lung, the right side of the brain, the heart, the tongue, etc.
