Ninety cases of salivary gland tumors pathologically diagnosed at the Department of Oral and Maxillof acial Surgery, Nara Medical University between October 1981 and June 1997 were clinicostatistically analyzed.
The results were as follows:
1. The subjects were 46 male and 44 female patients.
2. Their mean age was 45.1 years for benign tumor and 56.4 years for malignant tumor.
The mean age for the benign tumor was similar in both sexes. Males were about 25 years older than females for malignant tumors.
3. Histologically, 72 benign tumors were composed of 61 pleomorphic adenomas, 9 Warthin tumors, 1 myoepithelioma, and 1 cystic lymphangioma. The 18 cases of malignant tumors were composed of 12 adenoid cystic carcinomas, 2 mucoepidermoid car cinomas, 2 basal cell carcinomas, 1 squamous cell carcinoma, and 1 carcinoma in pleomorphic adenoma.
4. The primary tumor sites were the major salivary gland in 36 cases and the minor salivary gland in 54 cases. The most common primary site was the parotid gland for the major salivary gland in 25 cases and the palate for the minor salivary gland in 37 cases.
5. Painless swelling was a characteristic symptom found in all cases of benign tumors. The first clinical findings of malignant tumors were mixed symptoms of pain and others in addition to swelling.
6. Surgical treatment was performed for all benign tumors. For malignant tumors, 4 cases were treated with surgery alone and 11 cases with radiation and/or chemotherapy in addition to surgery.
7. There was no recurrence in any benign tumor case. These cases demonstrated favorable prognoses. The 5-year and 10-year cumulative survival rates were 55.0% in all cases, 100% for the stage I and II group, 41.6% for stage III and IV group, 46.7% for N (1-3) group, and 75.0% for N (0) group, respectively.

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A markedly-increased incidence of malignancy in renal allograf t recipients has been recognized in the forefront countries of transplantation. Recently, a clinical concern about the occurrence of malignancy after renal transplantation has arisen as the rate of long-term graft survival has improved in Japan.
This paper describes a case of multiple malignant lymphomas occurring in the gingiva 7 years after renal transplantation. A 45-year-old male complained of gingival painless swelling. Clinically, gingival hyperplasia induced by cyclosporin was diagnosed so gingivoectomy was performed.
Microscopic findings indicated malignant and diffuse lymphoma of pleomorphic type (LSG) .

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A case of advanced osteosarcoma arising from the left maxilla was presented. The patient was a 32-year-old female who had undergone a surgery for benign osteoblastoma of the left maxilla 7 years previously. She had a remarkably large mass which covered all of the left face. The histopathological diagnosis of biopsy specimens was osteosarcoma. After high-dose methotrexate therapy and radiotherapy, the tumor was reduced in size. A reduction operation (tumor resection) was performed as the palliative treatment. The residual tumor had been stable after operation, but it metastasized to both the right upper lung and the right side of the brain thereafter. In spite of stereotactic multiple area radiotherapy performed on the right side of the brain, she died of respiratory failure. Autopsy revealed metastatic lesions in the right upper lobe of the lung, the right side of the brain, the heart, the tongue, etc.

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Three cases of cemento-ossifying f ibroma were studied clinicopathologically. The tumors were found in three males. The patients' ages at their first visits was 14, 43, and 47 years; the mean age was 34.7 years. All three cases occurred in the mandibular molar region. Radiographically, these lesions were demarcated in all cases. X-ray showed mixed radiolucent/radiopaque shadow in all cases. Tumor enucleation and autogenious iliac spongious bone marrow graft were performed in all cases. There were no recurrence cases. Macroscopically, these tumors were unencapsulated. Microscopically, they were composed of fibrous tissue accompanied by various maturation of cementum-like and/or bone-like tissue.

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Although oral erythroplakia is accepted as one of the oral precancerous lesions with high potentiality for malignant transformation, there has been few reports about it because the incidence is rarer than oral leukoplakias. Three cases of oral erythroplakia during six years were presented. These lesions clinically were bright red, had a clear outline, and contacted instable dentures. Pathologically, they were diagnosed as moderate or severe dysplasia and one case transformed to invasive carcinoma after a long-term clinical course.
This case supports the opinion that oral erythroplakia should be resected as a malignant lesion as soon as possible.

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Odontomas are the most common of all odontogenic tumors of the jaw, commonly varying in size of less than 30mm. This report describes a recent case of large complex odontoma, 46×35×34mm, located in the maxilla.
Review of literatures on odontoma, of which the size is more than 30mm in diameter in various articles from 1960 to 1997, was performed.

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