Combined treatment for two advanced carcinomas of the buccal mucosa with local hyperthermia

Abstract

Multimodal treatment with hyperthermia for two advanced carcinomas of the buccal mucosa was discribed.
Case 1: A 61-year-old man had squamous cell carcinoma of the well differentiated type (T3N2bM0, UICC 1987) . Five cycles (PEP: total 72.5mg, MMC: total 50mg) of chemotherapy with PM administration were carried out. Simultaneously, primary tumors and cervical metastases were irradiated eighteen times with ⁶⁰Co (total dose: 36Gy) using hyperthermia. OK-432 totalling 44.5 KE was given before surgery.
Following excision of primary tumor and total neck dissection, immediate reconstruction, using D-P flap for full-thickness defects of the cheek was performed.
Case 2: A 69-year-old man had squamous cell carcinoma of the well differentiated type (T4N2bM0) . Chemoradiotherapy was carried out with ⁶⁰Co (total dose: 40.5Gy for the primary tumor, 60.5Gy for cervical metastases) with 1500mg of CDDP, 70mg of PEP and 2000mg of 5-FU were also administered. Simultaneously, hyperthermia for the neck was done 9 times 1 day a week. Before surgery, OK-432 totalling 40.4 KE was given. Both patients were followed for a period of 4-years or 2-years and 7 months, respectively. No recurrence or distant metastasis was detected.