Clinico-pathological studies on effects of induction chemotherapy in squamous cell carcinoma of gingiva

Abstract

Clinico-pathological studies of 10 cases of gingival cancer removed after induction chemotherapy were made. Either Bleomycin, Methotrexate or Cisplatin was given to all patients for induction chemotherapy. After induction chemotherapy, we applied various surgical treatments to gingival cancers according to the grade of clinico-pathological malignancy and the surgeries' therapeutic effects and received positive results. Based on the initial clinical and histological findings, it seems there is a very close correlation between induction chemotherapy and the grade of clinico-pathological malignancy.
It seems that upon the first evaluation of the clinical and histological findings, subsequent induction chemotherapy and surgical procedures, taking into account the malignancy grade, will help to improve the prognosis of gingival cancers.