A case of elderly patient with carcinoma of lower gingiva which dramatically responded to oral administration of UFT

Abstract

A case of carcinoma of the lower alveolous and gingiva in an 80-year-old patient is presented. Since the histopathologic diagnosis of squamous cell carcinoma was made, UFT^® was administered as an oral antitumor drug, resulting in the disappearance of the oral tumor clinically and histopathologically in three weeks.
An immunohistochemical study on the expression of metallothionein (MT) and proliferating cell nuclear antigen (PCNA) was conducted.
Expression of MT was observed around in cancer cell nest. Percentage of MT positive cancer cells in the tumor was very low (18.2%) . The profile of distribution of MT in tumors was similar to that of PCNA.