Abstract
We encountered a case of oral cancer who developed neuroleptic malignant syndrome due to methylphenidate hydrochloride used to shake off sleepiness for opioid.
A male of his 70s in the mandibular gingival carcinoma visited our hospital. And the tumor was resected. Postoperatively wound pain continued, therefore using morphine for pain control was good. However, since sleepiness did not decrease, the oral administration of methylphenidate hydrochloride was initiated. After administration for 3 days, the CPK level to 4,988 IU/l, the WBC level to 12,750/mm3 increased. Facial redness, perspiration, an increased pulse, general malaise, and decreased appetite were observed. Neuroleptic malignant syndrome was suspected, and the administration of this drug was discontinued. The symptoms improved after 6 days.
