Hunter舌炎に対するビタミンB₁₂内服療法の臨床的検討

抄録

Hunter glossitis is a relatively rare disease caused by vitaminB₁₂ deficiency. We clinically studied six cases of Hunter glossitis caused by vitamin B₁₂ deficiency. All cases complained tongue pain and dysgeusia, and they showed atrophy of lingual papillae and vitamin B₁₂ deficiency in blood examination. Macrocytic anemia was found out in five cases but one case was not anemia. Two cases were under treatment of chronic gastritis and three cases were total gastric resection in past. Untreated atrophic gastritis was found out in one case by upper gastrointestinal endoscopy. We treated all cases by oral administered vitamin B₁₂ therapy 1500 µg/day. After this therapy, red smooth tongue, oral pain, dysgeusia and level of vitamin B₁₂ in blood were improved in all cases.
It is popular that the treatment of vitamin B₁₂ deficiency is based on parenteral vitamin B₁₂ administered intramuscular injection. But recently, a few reports documented positive results following oral vitamin B₁₂ therapy. As the result of these cases, oral administered vitamin B₁₂ therapy was effective to Hunter glossitis.