Abstract
The objective of this study was to document the safety of tramadol hydrochloride/acetaminophen combination tablets for patients with post-tooth extraction pain. A total of 297 from 299 patients, who were enrolled in this study between January 2012 and January 2013, were evaluated. Patient demographics, administration characteristics, and safety, as well as drug effectiveness data were analyzed. The most common administration was one-day administration（n=93, 31.3%）and two tablets once a day（n=87, 29.3%）. Common side effects observed with active treatment were nausea（n=69, 23.2%）and vomiting（n=28, 9.4%）. Multiple logistic regression analyses revealed that females（p=0.013）and low body mass index（p=0.019）were identified as potential risk factors of nausea and vomiting occurrence. The present surveillance supported the overall safety profile of combination tablets in patients with post-tooth extraction pain.
