In the super-aged society, practice of oral care as a dental approach and prevention of oral flail will be essential in the future, and the importance of dental needs is attracting attention in the field of medical and nursing care for the elderly. In cases where it is difficult to rely on mechanical cleaning with a toothbrush alone, the combination of chemical cleaning with chemical solutions would be effective. Currently, the use of mouthwashes and mouthwashes at the discretion of dentists, dental hygienists, caregivers, and nurses is practiced based on their knowledge of the antimicrobial action of the products and empirical clinical experience. In the mechanism of action of mouthwashes and rinses, we have only studied the antimicrobial effects of mouthwashes and rinses on the bacteria that cause infection, but we have also studied the reactive oxygen species(ROS)from inflammatory cells that play an important role in oral inflammation and defense against bacterial infection. It is only reported that the antioxidant effects of ROS to reduce the oxidative stress caused by ROS has been investigated indirectly. Evidence for oral health care products that protect against oral infections should include not only antimicrobial activity but also antioxidant activity that reduces oxidative stress caused by ROS. Therefore, evidence for oral health care products that implement oral care to protect against oral infections requires not only an examination of antimicrobial action, but also an examination of antioxidant action by ROS. Since we have established an antioxidant evaluation method by electron spin resonance(ESR)method for the development of drugs, food and beverage products, and supplements, we used the antioxidant evaluation of mouthwashes and mouthwashes to investigate the antioxidant evaluation. The antimicrobial activity of Listerine® natural care(Listerine NC)and Neustelline® Green Gargle(Neostelline), which are widely used as mouth rinses and mouthwashes, was confirmed in this study, but the antimicrobial effect of Listerine NC and Neosterine in the concentrations used was more than sufficient and comparable to that of hydrogen peroxide(H2O2), which is used as a disinfectant. In the antioxidant effects of mouthwashes and rinses, some were found to have excellent antioxidant effects, such as Listerine NC and sodium bicarbonate, but others, such as Neustelin, did not have strong antioxidant effects. In this study, Listerine NC and sodium bicarbonate were found to have a coordinated effect on the antibacterial and antioxidant effects of mouthwashes and rinses. In addition, from the viewpoint of safe antimicrobial action, further evidence of appropriate concentration of antimicrobial action in the oral environment will be needed in the future by examining the effects of excessive concentrations of mouthwashes and rinses on the oral flora. We hope to develop mouthwashes and rinses based on these evidences in the future.