Oral ulceration of the left palate induced by dipeptidyl peptidase-4 inhibitor（sitagliptin）：A case report

Abstract

Dipeptidyl peptidase（DPP）-4 inhibitors are widely used for the treatment of type 2 diabetes mellitus. Recently, several reports have described oral ulceration associated with relatively new drugs such as nicorandil, low-dose methotrexate, and bisphosphonate. We herein report a case of a patient who developed oral ulceration as a result of taking the DPP-4 inhibitor, sitagliptin. The patient was a 64-year-old woman with oral ulceration of the left palate. Topical steroid treatment was ineffective. After sitagliptin cessation, the lesion epithelialized within 3 weeks. To our knowledge, this is only the second case report of oral ulceration induced by DPP-4.