抄録
Chemoprophylaxis by means of antibiotics is of great importance when such dental pro-cedures as extractions, infective root canal treatment and deep scaling are carried out in case of heart disease, immunocompromised patients, recent heart surgery cases, diabetics mellitus and others with fundamental disorders in which infection is liable to arise.
In the present study, we have compared the effects of normal dosages of various antibiotics administered to healthy volunteers at the same time examining the changes in drug sensitivity and in the concentrations of these substances in the blood as well as the effects of eating. Our results and conclusions are as follows;
1. Administration of amoxicillin (AMPC), talampicillin (TAPC) and clindamycin (CLDM) on an empty stomach was efficacious.
2. Amoxicillin (AMPC) is recommended for postprandial administration.
3. Further study is required in relation to dosages, including those appropriate in cases of infective endocardits.
