Abstract
CFTM-PI was administered to 153 patients at single oral dose of 50 mg, 100 mg, or 200 mg, and the blood concentration of active agent CFTM at the wound site after exodontia was determined. When the blood concentration was set at 0.2 μg/ml (MIC80) as a chemoprophylactic target level, the concentrations achieved over the target level are 39 % (9/23 cases) in 50 mg administration group, 76 % (41/54 cases) in 100 mg group and 80 % (39/49 cases) in 200 mg group during 60-240 minutes after the administration.
From these results, it is indicated that CFTM-PI is a useful agent for the prophylaxis and the treatment of odontogenic infections with dosage scheduled at 200 mg 3 times a day.
