歯科薬物療法
Online ISSN : 1884-4928
Print ISSN : 0288-1012
ISSN-L : 0288-1012
抗真菌剤Fluconazole投与後の薬物体内動態について
―血中濃度と唾液中濃度の検討―
竹部 幹浩玉繁 雅之中島 仁一成田 令博内田 安信高橋 寛高橋 則行
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1991 年 10 巻 1 号 p. 62-66

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Fluconazole, a triazole antifungal agent, was studied for its pharmacokinetics and reliability for therapeutic drug monitoring (TDM) .
The results obtained are as follows,
1) The blood and saliva concentrations of Fluconazole after oral administration ran parallel and were almost equal.
2) When an oral dose of 200 mg Fluconazole was administered, saliva concentration reached 75 % Inhibitory concentration (IC75) for almost all oral candida activities, and especially for Candida albicans it reached a comparable result as from an oral dose of 100 mg Fluconazole.
3) Saliva concentration is similar to that of the blood level, thus, this indicates that the saliva concentration is a reliable measure for TDM.
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