Abstract
The distribution of Sparfloxacin (AT-4140) was measured in New Zealand White rabbits after oral administration at a dose of 20 mg/kg.
Sparfloxacin was detected in serum, tongue, gingiva, submandibular gland, parotid gland, cervical lymph node and mandibular bone.
Pharmacokinetic parameters were calculated from the means of serum levels and each tissue level using two compartment model and moment analysis.
