抄録
In the present study, we have measured the serum level and saliva concentration of Sparfloxacin (SPFX) after a single administration of SPFX (200 mg) to the ten volunteer with cross over test under two conditions, fasting and nonfasting.
A pharmacokinetic study was performed using one compartment model. The parameters calculated were as follows :
Serum Saliva
fasting nonfasting fasting nonfasting
Tmax (h) 4.41 4.30 4.28 4.35
Cmax (μg/ml) 1.23 1.33 0.98 0.92
T1/2 (h) 10.92 11.20 11.55 11.55
AUC (μg·h/ml) 25.27 27.27 21.17 19.53
