Fundamental studies of Cefixime (CFIX) in Mxillofacial surgery

Abstract

We carried out fundamental studies to evaluate the usefulness of Cefixime (CFIX) in maxillofacial surgery, and obtained the following results.
1) The mean values of concentrations of CFIX after administration of 200mg P.O. to non-fasted patients were 2.42μg/ml (5 hr), 1.79μg/ml (7 hr) in serum, 0.95μg/ml (5 hr), and 0.65μg/ml (7 hr) in blood in wound. Gingival concentrations of CFIX were 0.21-1.17μg/g except 6 N.D.
2) The antibacterial activity of CFIX against 65 Streptococcus sp. clinically isolated was equivalent to those of Ampicillin (ABPC), Cefteram (CFTM), Cefuroxime (CXM) Ofloxacin (OFLX) and superior to that of Cefaclor (CCL) at MIC₈₀, but against 30 Staphyloccoccus sp. CFIX showed inferior antibacterial activity to other antibiotics. Among all antibiotics, CFIX showed the strongest antibactrial activity against arerobic gram-negative organisms.
3) It was considered that CFIX was effective in the treatment of mild and moderate oral infections.