Cefditoren pivoxil (ME 1207) 多施設臨床試験の臨床分離株に対する細菌学的検討

抄録

Bacteriological studies were carried out in the field of oral and maxillofacial surgery. The total number of isolated organisms were 100 strains.
The results were as follows :
1. Oral streptococci were most frequently datected from dental infections followed by oral group Bacteroides.
2. Of the 46 patients included in this study, 20 had monomicrobial infections and 26 had polymicrobial infections. Polymicrobial infections due to aerobes plus anaerobes were the most frequent, while those due solely to anaerobes were less frequent.
3. The minimum inhibitory concentration (MIC) of ME1206 against oral streptococci ranged from ≤0.025 to 0.20μg/ml and its MIC₉₀ was 0.20μg/ml.
Compared with the other 5 drugs tested, ME1206 proved to be the most effective.
4. MIC₉₀ of ME1206 against Bacteroides and against Peptostreptococcus it was 0.78μg/ml and 0.39μg/ml.
From these results, we concluded that ME1207 is effective against infections in the fields of oral and maxillofacial surgery.