Abstract
A clinical study on CZX for assesment of a prophylactic effectiveness against post-operative infection in oral surgery was carried out. CZX was administered by intravenous injection to 34 patients (Group I; 18 cases of progenia, Group II; other 16 cases) after surgery. The fever index was calculated by the method of Ledger. A total score for objective evaluation of postoperative infection was determined based on the sum of scored clinical data for body temperature, leucocyte count, ESR, CRP and bacterial appearance. The higher the score, the higher was the possibility of post-operative infection. The following results were obtained :
1) The fever index was 7.44±9.85 degree hours in total cases, 13.2±10.50 degree hours in Group I, and 0.98±1.99 degree hours in Group II.
2) According to the total score for prophylactic effectiveness, out of 34 cases, 8, and 2 cases had 1, 2, and 3 points. The remaining 16 cases had 0 points.
3) Post-operative clinical courses, such as a dehiscence and infection of surgical wound were not observed.
4) No side effects were detected.
Based on the present results, CZX appeares safe and quite useful for preventing post-operative infection in oral surgery.
