Effect of Casein phosphopeptide on Phagocytic Capacity and Intracellular Oxidative Function of Polymorphonuclear Neutrophils

Abstract

The effect of CPP on neutrophil functional impairment induced by periodontopathic bacteria was assessed. Incubation of neutrophils in the presence of Porphyromonas gingivalis culture supernatant induced a significant decrease of intracellular reactive oxygen production. Whereas incubation with Streptococcus sanguis did not. CPP restored reactive oxygen production and phagocytosis of neutrophils treated with Porphyromonas gingivalis culture supernatant in a dose-dependent fashion. Addition of CPP to neutrophils incubated with PBS enhanced neutrophil phagocytizing functions dose-dependently as well. Thus, administration of CPP combined with the currently available therapeutics may offer a novel means in controlling periodontal diseases.