抄録
The effect of CPP on neutrophil functional impairment induced by periodontopathic bacteria was assessed. Incubation of neutrophils in the presence of Porphyromonas gingivalis culture supernatant induced a significant decrease of intracellular reactive oxygen production. Whereas incubation with Streptococcus sanguis did not. CPP restored reactive oxygen production and phagocytosis of neutrophils treated with Porphyromonas gingivalis culture supernatant in a dose-dependent fashion. Addition of CPP to neutrophils incubated with PBS enhanced neutrophil phagocytizing functions dose-dependently as well. Thus, administration of CPP combined with the currently available therapeutics may offer a novel means in controlling periodontal diseases.
