Abstract
The purpose of this study was to evaluate the clinical effect of low dose daily use of Roxythromycin (RXM) for chronic periodontal disease, and the effect on phagocytosis and intracellular killing of polymorphonuclear leukocytes (PML) was discussed.
Five men and five women, with a mean age of 45.5 years (range 30-63), were the subjects in this study. RXM, a dosage of 150 mg once a day, was administered for two weeks. No other treatment and instruction were performed. Most clinical parameters, which are used to assess the degree of inflammation of periodontal tissues, had decreased significantly after the administration. Some causative bacteria remained in the gingival sulcus after administration. In the evaluation of the effect on PML function, there was no significant difference between before and after administration of RXM. It was considered that this reaction was favorable to the periodontal tissues as an anti-inflammatory factor.
Due to the results of this study, it was concluded that the use of RXM was effective for reducing the inflammatory reactions of chronic periodontal diseases. In addition, it was suggested that the anti-inflammatory effect was caused not only by the antibiotic effect but also by the immunological effect of RXM.
