Abstract
Cefdinir was administered in a oral dose of 100 mg three times a day to 55 patients with odontogenic infections to investigate the clinical and bacteriological effects. The overall clinical efficacy rate of cefdinir was 89.1 %, 92.7 % (38 of 41 patients) for periodontitis and 83.3% (10 of 12) for pericoronitis.
Of these patients, 5 had diabetes. Cefdinir was effective in 4 patients. The bacteriological effect was obtained as follows : The eradication rates were 84.0% (42 of 50 strains) for oral streptococci, 88.2% (15 of 17) for Peptostreptococci, and 100% (14 of 14) for Gram negative anaerobe bacilli (Prevotella, Porphyromonas, Fusobacterium) . The eradication rates were 83.6% for all the aerobic bacteria and 90.6% for the anaerobic bacteria. The clinical efficacy and bacteriological eradication rate in this study was confirmed to be nearly the same as those obtained when cefdinir was marketed in 1991.
