Abstract
Oral symptom of chronic GVHD (graft-versus-host-disease) prolongs the illness period of a patient with an eating disorder.
Allopurinol mouthwash (ALP) was used for a 35-year-old male who developed an eating disorder due to an oral symptom of chronic GVHD after bone marrow transplantation after diagnosis of a myelodysplastic syndrome. As a result, the oral symptoms disappeared 40-60 days after gargling was started which was early in comparison with the change of constitutional symptoms such as trunk efflorescence, GOT, and GPT, and its efficacy was suggested.
ALP was reported for prevention and treatment of the stomatitis, which develops during cancer chemotherapy, with the usefulness, and the action is reported with the anti-inflammatory action mainly on active oxygen scavenging and generation inhibitory effect. As for therapy of chronic GVHD, administration of the immunosuppressive agent is central, and the local therapy has not been established. The use of ALP was convenient only in gargling, and no side effect was recognized, so it seemed to be a useful drug.
