Abstract
The Phamacokinetics of ABPC were investigated to compare the effectiveness of intravenous drip infusion of 1.0g of ABPC followed by two successive oral administrations of 0.5g of LAPC with that of three successive oral administrations of 0.5g of LAPC to outpatients with moderate to severe infections in the oral and maxillofacial regions.
The results were as follows:
1. In the subjects receiving drip infusion of 1.0g ABPC and two successive oral administrations of 0.5g LAPC, the concentration of ABPC reached a peak of 46.34μg/ml soon after drip infusion was stopped. Thereafter, the blood concentration was maintained over 3.8μg/ml for about 6 hours.
2. When the two administration methods were compared, the blood concentration of ABPC after combination therapy was higher from the initiation of administration to 4 hours after the end of administration.
3. Since blood concentrations were well maintained, this combination therapy may be effective against resistant oral streptococci, as well as other anaerobic gramnegative bacillus.
