歯科薬物療法
Online ISSN : 1884-4928
Print ISSN : 0288-1012
ISSN-L : 0288-1012
口腔外科領域におけるCefaclorの基礎的, 臨床的検討
難波 良司田口 雅史伝 春光南 良尚山本 剛義中尾 薫島田 桂吉
著者情報
ジャーナル フリー

1983 年 2 巻 2 号 p. 79-93

詳細
抄録
Fundamental and clinical studies were performed on a new cephalosporin antibiotic, CCL, in the field of oral surgery, and the following results were obtained:
1. The MIC was measured using clinically isolated bacteria, and CCL was compared with CEX, AMPC and CXD. CCL was found to be slightly inferior to AMPC against 21 strains of G (+) bacteria, but superior to other drugs in anti-bacterial activity against 85 strains of G (-) bacteria.
2. This drug was administered orally at a dose of 500mg after meals to study the concentration in serum, transfer into oral tissue, and successive changes of concentration in blood using volunteers. The mean concentration in serum was 3.33μg/ml after 60 min and 4.20μg/ml after 120 min. The ratio of concentration in the oral tissue to that in serum was 0.32-2.13 for the gingiva, 0.49-0.60 for the cyst wall, and 0.07-0.26 for the mandibular bone. The successive changes in serum were 0.64μg/ml after 30 min, 1.78μg/ml after 60 min, 2.65μg/ml after 90 min, 3.03μg/ml after 120 min, 2.89μg/ml after 180 min, 2.15μg/ml after 240 min, and 0.44μg/ml after 360 min.
3. This drug was administered orally to 21 cases of infections in this department, and the results were markedly effective in three cases, effective in 15 cases, slightly effective in one case, ineffective in one case, and unknown in one case, the efficacy rate was 90%.
4. The side effects were gastrointestinal disorder in one case, a slight feeling of heaviness in the head in one case, slight thrombocytosis in one case, and hepatic disorder in one volunteer.
著者関連情報
© 日本歯科薬物療法学会
前の記事 次の記事
feedback
Top