Abstract
The purpose of this study was to discuss the evidence of off-label use in oral therapeutics and pharmacology.
We made a fact-finding study of off-label uses of medicines, by questionnaire, in a dental practice survey of 18 private dental college and university hospitals in Japan, and inquired into evidence in the literature, and tried to check the treatise on clinical studies with the type of evidence by the Agency for Health Care Policy and Research (AHCPR) .
The total number of off-label uses were 61 cases, as a result of the fact-finding study. The 21 treatises on case reports written from 1967 to 1999 of Cepharanthin (trouble in oral mucosa), which was often used, were obtained. They were considered to correspond with level III by AHCPR.
It is hoped that the indication is spread by clinical studies of the height-grade evidence in dental practice after this.
