Abstract
Therapeutic effects of a new anti-inflammatory drug (156-S) were studied in patients with pain after surgical removal of impacted teeth. 154 out of 185 patients were randomly and double-blindly divided into 3 groups: group I received 400 mg of 156-S, group II received 200 mg of 156-S and group III received placebo all orally and at the onset of pain.
Clinical effects were statistically analysed for the 3 groups, and the following results were obtained:
1) Analgesic effect, which was marked an hour after administration of the drug, was significantly stronger in group I and II than in group III (p<0.05) .
2) Analgesic effect appeared in a significantly shorter time in group I and II than in group III (p<0.05) .
3) Although no significant differences between group I and II could be proved statistically, group I showed greater improvement in respect to analgesic effects than group II.
4) No specific adverse reactions were detected with the above dosages of 156-S.
