ORAL THERAPEUTICS AND PHARMACOLOGY
Online ISSN : 1884-4928
Print ISSN : 0288-1012
ISSN-L : 0288-1012
Volume 4, Issue 1
Displaying 1-7 of 7 articles from this issue
  • TAZUKO SATOH, NORIO YOSHINARI, OSAMU MUNEMURA, YASUHIDE OHSHIMA, YOSHI ...
    1985 Volume 4 Issue 1 Pages 1-10
    Published: June 30, 1985
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
    Oriental traditional medicine“Tsumura Hangeshashintoh”which contains Pinelliae Tuber, Scutellariae Radix, Glycyrrhizae Radix, Zizyphi Fructus, Ginseng Radix, Coptidis Rhizoma, Zingiberis Siccatum Rhizoma, was used for 28 patients aged from 10 to 67 years old who had suffered oral mucosa lesion from January to August in 1984. The daily dose was 7.5 g taken orally and admitted 2.5 g before every meal.
    The results were as follows :
    1) The evaluation of the clinical effects were taken after 2 and 4 weeks. The clinical improvement after 4 weeks held glossitis 70.0%, lichen planus 71.4%, recurrent aphtha 100%, aphthous stomatitis 100%, and hairy tongue 25.0%, and the total effectiveness was 71.4%. So that this drug was pretty effective without hairy tongue.
    2) The clinical usefulness obtained were glossitis 60.0%, lichen planus 71.4%, recurrent aphtha 100%, aphthous stomatitis 66.7%, and hairy tongue 25.0%, and the total usefulness was 64.3%.
    3) Of relation between the disease and symptoms, 82.1% of the patients held neurotic or abdominal symptoms. And they agreed with the oriental medical“shoh” for“Hangeshashintoh.”
    4) No abnormalities or side effects were observed during clinical examination.
    We found“Tsumura Hangeshashintoh”was effective for the disease of oral mucosa at first choice.
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  • Observation by the electric dental pulp tester
    HARUHIKO MIYAKO, KIMIHIKO MISHIMA, NOBUKO TSUBAKI, SEIJI HENMI, YOSHIH ...
    1985 Volume 4 Issue 1 Pages 11-18
    Published: June 30, 1985
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
    With a purpose to observe the effect of analgesics and combination of an analgesic agent and an anti-anxiety agent, pain tolerance thresholds were evaluated by electrical teeth stimulation using an autoelectric dental pulp tester.
    The subjects were ten volunteered university students, including four males and six females, all in good health ages ranged from 20 to 22 years.
    As tested tooth, the healthy one was chosen from anterior teeth and molar teeth.
    Three kinds of drugs were administrated, an analgesic anti-inflammatory agent (prano-profen), the combination of pranoprofen and an anti-anxiety agent (clotiazepam), and placebo.
    Conclusion : Females showed the rises of thresholds for all the drugs including placebo, while males showed only for the real drugs, pranoprofen and the combination of prano-profen and clotiazepam. Compared with placebo, the rises of thresholds for pranoprofen and the combination of pranoprofen and clotiazepam were higher in males than in females.
    These observations suggested that autoelectric dental pulp tester was useful as an objective indicator for measuring pain tolerance thresholds.
    The observations also suggest that pre-administration of drugs, such as an anti-inflammatory agent and the combination of an anti-inflammatory agent and anti-anxiety agent, would be efficacious for raising patients' pain tolerance thresholds and comfort their pains in painfull dental treatment.
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  • A double-blind controlled study for determination of optimal dosage
    RYOSUKE SHIBA, TAKETOSHI GUNJI, HIROAKI TANIOKA, TATSUYA YASUNAMI, MAS ...
    1985 Volume 4 Issue 1 Pages 19-27
    Published: June 30, 1985
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
    Therapeutic effects of a new anti-inflammatory drug (156-S) were studied in patients with pain after surgical removal of impacted teeth. 154 out of 185 patients were randomly and double-blindly divided into 3 groups: group I received 400 mg of 156-S, group II received 200 mg of 156-S and group III received placebo all orally and at the onset of pain.
    Clinical effects were statistically analysed for the 3 groups, and the following results were obtained:
    1) Analgesic effect, which was marked an hour after administration of the drug, was significantly stronger in group I and II than in group III (p<0.05) .
    2) Analgesic effect appeared in a significantly shorter time in group I and II than in group III (p<0.05) .
    3) Although no significant differences between group I and II could be proved statistically, group I showed greater improvement in respect to analgesic effects than group II.
    4) No specific adverse reactions were detected with the above dosages of 156-S.
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  • MINORU ARIIZUMI, YUSUKE IKEMURA, KAZUNARI TANABE, KAZUYA TAMURA, MINOR ...
    1985 Volume 4 Issue 1 Pages 28-40
    Published: June 30, 1985
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
    A clinical trial comparing new-type Aphtasolon (which base material was improved old-type Aphtasolon) and old-type Aphtasolon in respect of adhesion time and improvement of the symptoms was performed.
    Thirty patients (10 to 71 years old, 14 males and 16 females) and 30 volunteered dental students participated in this study. To evaluate this study, case cards (Figs. 1 and 2) were used.
    The results can be summarized as follows :
    1) New-type Aphtasolon was better than old-type Aphtasolon considering“adhesiveness, ”“easy to apply, ”“rough feeling, ”“taste.”No difference was observed considering“slimy and sticky feeling” (Table 1) .
    2) It is considered that both the new and the old-type Aphtasolon, were useful for improvement of the diseases tested. Both types of Aphtasolon were effect for spontaneous pain and contact pain right after application, and gradual effect on other symptoms such as burning sensation, rubor, swelling and bleeding (Tables 1-11) .
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  • HIROSHI TAKAI, KAZUHIKO NISHIYAMA, TAKASHI KIMURA, TAKASHI CHIBA, HIDE ...
    1985 Volume 4 Issue 1 Pages 41-49
    Published: June 30, 1985
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
    So-called maxillary prosthesis for patients after resection of the jaw is usualy an unfa-vourable condition for mastication, because such patients have no alveolar process, a few teeth for clasp setting and defects of other supporting structure for prosthesis.
    The authors examined the effect of adhesion ability of polyacrylic acid natrium in five cases of maxillary prostheses and thirty six cases of unstable plate dentures.
    The results were summarized as follows ;
    1) Stability and adhesiveness of prosthesis to mucous membrane were improved by use of this agent.
    2) Sensation of taste was not changed.
    3) Local irritation and other side effects were not recognized.
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  • MASAFUMI TAGUCHI, TAMOTSU OKUSHA, RYOJI NAMBA, HARUMITSU TSUTOO, YOSHI ...
    1985 Volume 4 Issue 1 Pages 50-60
    Published: June 30, 1985
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
    Fundamental and clinical studies in the field of oral surgery were carried out on Cefro-xadine (CXD) . The following results were obtained.
    1) Antibacterial activity of CXD was compared with CCL, CEX and AMPC. Results show that it was similar or slightly superior to CEX and was slightly inferior to CCL.
    2) The concentrations in serum and the oral tissues 60 minutes after administration of 500mg in fasting objects were 13.2+1.4μg/ml (mean ±S.E.) in serum, 65.1±1.2μg/ml (mean ±S.E.) in gingiva and 0.18μg/g in dental follicle. The mean serum concentration in non fasting objects were 0.25μg/ml at 30 min, 0.75μg/ml at 60 min, 5.3μg/ml at 90 min, 10.5μg/ml at 120 min, 6.34μg/ml at 240 min and 1.1μg/ml at 360 min.
    3) Fifteen cases with oral infections were treated with 1, 500 mg Cefroxadine per day. Therapeutic responses were good in 12 cases, fair in 1 case and poor in 2 cases ; the efficacy rate was 80%.
    4) Side effects associated with CXD were not noted except for 1 case of exanthema.
    5) According to these results, CXD is considered to be a useful antibiotic for mild or moderate oral infections and for prevention of post operative infection.
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  • MAYUMI YOSHIDA, TAKESHI SHIOTA, KEN-ICHI SAITO, ATSUSHI NAKAMURA, KOHJ ...
    1985 Volume 4 Issue 1 Pages 61-66
    Published: June 30, 1985
    Released on J-STAGE: June 08, 2010
    JOURNAL FREE ACCESS
    A case of toxoplasmosis involving the submental lymphonode of a ten-year-old girl treated with trimethoprim/sulfamethoxazole (TMP/SMZ) is reported. She attended our hospital complaining of painless swelling in the submental area. No apparent inflammatory reaction was found clinically, and the routine laboratory findings were normal. Diagnosis of toxoplasmosis of a lymphonode was made, depending on the serum antibody titer against toxoplasma (LA test; 1: 128) . After 64 days' administration of TMP/SMZ, the antibody titer decreased to 1 : 32 and the swelling of the lymphonode diminished. During the course of the treatment, no side-effects were observed.
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