Clinical study of Cephapirin (a Cephalosporin antibiotic for injection) applied to the oral and maxillo-facial infections and prevention of post-operative infections

Abstract

Evaluating the clinical validity of Cephapirin (Cefatrexyl for injection), which is known as an effective antibiotic mainly applied to gram-positive bacilli, we administered it to 5 patients who suffered from oral and maxillo-facial infection and to 16 patients for preventing post-operative infection. These cases were admitted and treated at our department between November 1984 and May 1985. Then the following results were obtained
1) Cefapirin was administered from 2 to 6 g by intravenous injection twice a day, for 3 to 19 days with an average of 6 days.
2) Researched cases were composed of 21 patients (12 men and 9 women) whose ages ranging from 14 to 76 years.
3) The efficacy rate of the drug was 80% in the group of infection such as severe acute osteomyelitis or phlegmone.
4) The efficacy rate was 100% in the group that using to preventing post-operative infections, after operations such as excision of tumor or cyst, or open reduction of jaw fructures.
5) Side effects were observed in 3 cases (14%), which were recorded as drug eruption, diarrhea and others. Various clinical examinations were performed in 10 cases, but any abnormal finding was not recognized during and after administration of Cefapirin.
As conclusion of this evaluation, it could be emphasized that Cefapirin was an useful antibiotic for primary severe infections and preventing post-operative infections in the oral and maxillo-facial regions.