Fundamental and clinical studies on latamoxef sodium in the field of oral surgery

MASAKO ARAKAWA; KANYA MATSUBARA; TAKESHI OSHIO; RYUZO KATO; MASARU MIYATA; YUICHI NAKAI; TOSHIMI MUROKI; TOSHIHIKO NAKASHIN; EISUKE FUJIMOTO; HIDEAKI SAKASHITA; KIYOMASA NAKAGAWA; KENZO TAMAI

doi:10.11263/jsotp1982.4.67

MASAKO ARAKAWA, KANYA MATSUBARA, TAKESHI OSHIO, RYUZO KATO, MASARU MIYATA, YUICHI NAKAI, TOSHIMI MUROKI, TOSHIHIKO NAKASHIN, EISUKE FUJIMOTO, HIDEAKI SAKASHITA, KIYOMASA NAKAGAWA, KENZO TAMAI

Author information

MASAKO ARAKAWA
Department of Oral Surgery, School of Medicine, Kanazawa University
KANYA MATSUBARA
Department of Oral Surgery, School of Medicine, Kanazawa University
TAKESHI OSHIO
Department of Oral Surgery, School of Medicine, Kanazawa University
RYUZO KATO
Department of Oral Surgery, School of Medicine, Kanazawa University
MASARU MIYATA
Department of Oral Surgery, School of Medicine, Kanazawa University
YUICHI NAKAI
Department of Oral Surgery, School of Medicine, Kanazawa University
TOSHIMI MUROKI
Department of Oral Surgery, School of Medicine, Kanazawa University
TOSHIHIKO NAKASHIN
Department of Oral Surgery, School of Medicine, Kanazawa University
EISUKE FUJIMOTO
Department of Oral Surgery, School of Medicine, Kanazawa University
HIDEAKI SAKASHITA
Department of Oral Surgery, School of Medicine, Kanazawa University
KIYOMASA NAKAGAWA
Department of Oral Surgery, School of Medicine, Kanazawa University
KENZO TAMAI
Department of Oral Surgery, School of Medicine, Kanazawa University

Keywords: Latamoxef sodium, Oral cavity, Cicatricial gingival tissue, Tissue concentration, Clinical effect

JOURNAL FREE ACCESS

1985 Volume 4 Issue 2 Pages 67-72

DOI https://doi.org/10.11263/jsotp1982.4.67

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Abstract

Fundamental and clinical studies were carried out on latamoxef sodium, a synthetic antibiotics of oxacephem group. Transfer of antibiotics to the gingiva and blood collected during oral surgical operation and their peak concentrations were determined by the cup-plate method after administration of latamoxef sodium in 25 cases.
Normal and cicatricial gingival tissues were comparatively examined. Peak concentrations of latamoxef sodium in the blood serum and the gingival tissues were obtained one hour after it was intramusculary administered. The peak concentration in the cicatricial gingiva was approximately 54.8% of those in the normal gingiva.
As a clinical study, the drug was administered intravenously by drip infusion to 53 cases postoperatively. The rate of effectiveness was 65.9%.
While latamoxef sodium is undoubtedly a superior antibiotics, in the oral cavity it is more effective as postoperatively infection preventer.

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