抄録
Fundamental and clinical studies were carried out on latamoxef sodium, a synthetic antibiotics of oxacephem group. Transfer of antibiotics to the gingiva and blood collected during oral surgical operation and their peak concentrations were determined by the cup-plate method after administration of latamoxef sodium in 25 cases.
Normal and cicatricial gingival tissues were comparatively examined. Peak concentrations of latamoxef sodium in the blood serum and the gingival tissues were obtained one hour after it was intramusculary administered. The peak concentration in the cicatricial gingiva was approximately 54.8% of those in the normal gingiva.
As a clinical study, the drug was administered intravenously by drip infusion to 53 cases postoperatively. The rate of effectiveness was 65.9%.
While latamoxef sodium is undoubtedly a superior antibiotics, in the oral cavity it is more effective as postoperatively infection preventer.
