Clinical effect of Midecamycin acetate on the oral infections

TAKESHI OSHIO; KANYA MATSUBARA; RYUZO KATO; KENZO TAMAI; SHIN-ICHI KITA; MITSUGU SUZUKI; NOBUO YOSHIZAWA; ISOO NOGUCHI; KAZUO NEMOTO; MASATOSHI OHNISHI; AKIRA KOTANI; KATSUTOSHI MOTEGI; ISAO FURUTA; YASUO ISHII; TAKUMI SATO; KEIKICHI SHIMADA; NOBUTAKA HORI; MASAHITO SUGIMURA; TADAYUKI SAKAMOTO; TAKESHI HAMADA; TOKIO OZAKI; SHUN-ICHIRO NAGAHATA; RYOSUKE SHIBA; MASATSUGU SHIMIZU; MASAHIRO YAMASHIRO

doi:10.11263/jsotp1982.5.67

TAKESHI OSHIO, KANYA MATSUBARA, RYUZO KATO, KENZO TAMAI, SHIN-ICHI KITA, MITSUGU SUZUKI, NOBUO YOSHIZAWA, ISOO NOGUCHI, KAZUO NEMOTO, MASATOSHI OHNISHI, AKIRA KOTANI, KATSUTOSHI MOTEGI, ISAO FURUTA, YASUO ISHII, TAKUMI SATO, KEIKICHI SHIMADA, NOBUTAKA HORI, MASAHITO SUGIMURA, TADAYUKI SAKAMOTO, TAKESHI HAMADA, TOKIO OZAKI, SHUN-ICHIRO NAGAHATA, RYOSUKE SHIBA, MASATSUGU SHIMIZU, MASAHIRO YAMASHIRO

Author information

TAKESHI OSHIO
Department of Oral Surgery, School of Medicine, Kanazawa University
KANYA MATSUBARA
Department of Oral Surgery, School of Medicine, Kanazawa University
RYUZO KATO
Department of Oral Surgery, School of Medicine, Kanazawa University
KENZO TAMAI
Department of Oral Surgery, School of Medicine, Kanazawa University
SHIN-ICHI KITA
Department of Oral Surgery, Asahikawa Medical College
MITSUGU SUZUKI
Department of Dentistry and Oral Surgery, School of Medicine, Hirosaki University
NOBUO YOSHIZAWA
Department of Dento-Oral Surgery, School of Medicine, Yamagata University
ISOO NOGUCHI
Department of Oral and Maxillofacial Surgery, National Defense Medical College
KAZUO NEMOTO
Department of Stomatology, Institute of Clinical Medicine, University of Tsukuba
MASATOSHI OHNISHI
Department of Oral and Maxillo-facial Surgery, Yamanashi Medical College
AKIRA KOTANI
Department of Dentistry and Oral Surgery, School of Medicine, Shinshu University
KATSUTOSHI MOTEGI
Department of Dentistry and Oral & Maxillofacial Surgery, School of Medicine, Hamamatsu University
ISAO FURUTA
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University
YASUO ISHII
Department of Dentistry and Oral Surgery, Fukui Medical School
TAKUMI SATO
Department of Oral Surgery, Shiga University of Medical Science
KEIKICHI SHIMADA
Department of Oral Surgery, School of Medicine, Kobe University
NOBUTAKA HORI
Department of Dentistry, Kyoto Prefectural University of Medicine
MASAHITO SUGIMURA
Department of Oral and Maxillofacial Surgery, Nara Medical University
TADAYUKI SAKAMOTO
Department of Dentistry and Oral Surgery, Wakayama Medical College
TAKESHI HAMADA
Department of Oral Surgery, School of Medicine, Tottori University
TOKIO OZAKI
Department of Oral Surgery, Kouchi Medical School
SHUN-ICHIRO NAGAHATA
Department of Oral and Maxillofacial Surgery, Kagawa Medical School
RYOSUKE SHIBA
Department of Oral and Maxillofacial Surgery, Miyazaki Medical College
MASATSUGU SHIMIZU
Department of Dentistry and Oral Surgery, Medical College of Oita
MASAHIRO YAMASHIRO
Department of Oral Surgery, School of Medicine, University of the Ryukyu

Keywords: Midecamycin acetate, Oral infectious disease, Clinical effect

JOURNAL FREE ACCESS

1986 Volume 5 Issue 2 Pages 67-77

DOI https://doi.org/10.11263/jsotp1982.5.67

Details

Abstract

The results of clinical studies on MOM for oral use, performed at 22 institutes in this country, are summarized in this protocol. The conclusions obtained is as follows:
1) Clinical efficacy of MOM oral administration was evaluated in 113 patients with oral infectious disease, and 82.3% responded to the drug.
2) Clinical efficacy of MOM at a daily dose of 600 mg was 83.2% based on committee-judgement and 80.0% based on doctors' judgement.
3) MOM shows antibacterial activity against aerobes, anaerobes and mixed infection cases.
4) In 4 of the 160 cases treated, gastrointestinal symptoms were appeared.
5) From the above results, it was concluded that MOM was a useful new antibiotic for the treatment of oral infections.

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