Abstract
TE-031 is a peroral macrolides antimicrobial agent. This drug belongs to a group of new macrolides which are synthesized from Erythromycin. In vitro, the susceptibility of microorganisms to this drug is the same as Erythromycin, however, it exhibits superior distribution to tissues as well as superior for urinary excretion.
In this study, the blood and saliva concentrations of TE-031 were compared by a crossover test in 10 healthy volunteers who were perorally given 150 mg of this drug while fasting and after a meal.
The distributions of the blood and saliva concentrations show similar patterns for fasting and after a meal. It is suggested that TE-031 is little influenced by food.
