歯科薬物療法
Online ISSN : 1884-4928
Print ISSN : 0288-1012
ISSN-L : 0288-1012
エノキサシン (ENX) における抜歯創内濃度と血中濃度の比較
山根 伸夫椎木 一雄
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ジャーナル フリー

1989 年 8 巻 1 号 p. 1-4

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We studied Enoxacin (ENX), a new-quinolon antibacterial agent, by comparing the drug concentration in tooth extraction wound blood with general concentration of the drug. The measurements were performed in 48 healthy volunteers 1, 2, 3, 4 and 6 hours after the drug was administered. The mean concentration in the tooth extraction wound blood and general concentration of ENX reached a peak after one hour. The drug concentration in the tooth extraction wound correlated well with the general blood concentration with a coefficient of correlation of 0.86. The drug was well accessed into the tooth extraction wound with a wound/blood concentration ratio of 1.323.
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