Abstract
CZX, 1 or 2g, was administered i.v. preoperatively to 16 patients operated on for maxillary sinusitis or with postoperative maxillary cyst, the serum, mucosa of the maxillary sinus and bone were obtained during operation, and the level of CZX in these tissues were measured. As a result, in the 1 g group (n=7) the mean serum level was 43.77 μg/ml, that in the maxillary sinus 16.2 μg/g and that in the bone 5.06 μg/g. In the 2 g group (n=9) the corresponding values were 55.24 μg/ml, 46.36 μg/g and 14.86 μg/g, respectively. The drug is considered to exist in concentrations higher than the MICs of many bacteria detected in diseases of the maxillary sinus.
Furthermore, this drug was administered to 31 cases to prevent postoperative infection and oral infection. Infections or aggravation of symptoms were found in no patients and results with an efficacy rate of 96.8% were obtained. Abnormal findings—a slight elevation of S-GOT and GPT—were found the only one patient. Thus, this drug is considered to be safe and highly useful in the field of oral surgery.
