A case of gingival hyperplasia induced by Nifedipine

MASAYO MIYATA; HIROFUMI MURASE; TAMOTSU YOSHIKAWA; KANJI KITAMURA; KINAI TOMITA; MASA-AKI KANAZAWA; TOHRU KAKU; KUMIKO SAKATA

doi:10.11263/jsotp1982.8.85

MASAYO MIYATA, HIROFUMI MURASE, TAMOTSU YOSHIKAWA, KANJI KITAMURA, KINAI TOMITA, MASA-AKI KANAZAWA, TOHRU KAKU, KUMIKO SAKATA

Author information

MASAYO MIYATA
Second Department of Oral Surgery, School of Dentistry, Higashi Nippon Gakuen University
HIROFUMI MURASE
Second Department of Oral Surgery, School of Dentistry, Higashi Nippon Gakuen University
TAMOTSU YOSHIKAWA
Second Department of Oral Surgery, School of Dentistry, Higashi Nippon Gakuen University
KANJI KITAMURA
Second Department of Oral Surgery, School of Dentistry, Higashi Nippon Gakuen University
KINAI TOMITA
Second Department of Oral Surgery, School of Dentistry, Higashi Nippon Gakuen University
MASA-AKI KANAZAWA
First Department of Oral Surgery, School of Dentistry, Higashi Nippon Gakuen University
TOHRU KAKU
Department of Oral Pathology, School of Dentistry, Higashi Nippon Gakuen University
KUMIKO SAKATA
Department of Pharmacy, Higashi Nippon Gakuen University Hospital

Keywords: Nifedipine, Diphenyl hydantoin, Gingival hyperplasia, Ca²⁺-antagonist

JOURNAL FREE ACCESS

1989 Volume 8 Issue 1 Pages 85-89

DOI https://doi.org/10.11263/jsotp1982.8.85

Details

Abstract

Gingival hyperplasia induced by Biphenyl hydantoin has been well docummented.
Recently reports have become available on gingival hyperplasia induced by the vasodilating drug Nifedipine, which is clinically and histologically similar to Piphenyl Hydantoin induced gingival hyperplasia.
We encountered a case of Nifedipine-induced gingival hyperplasia and performed gingivectomy after oral hygiene measures, this resulted in uneventful recovery, with no signs of recurrence.
The Nifedipine-induced gingival hyperplasia is rare and the mechanisms of action of Nifedipine are not clarified at present. But it is expected that the number of cases of Nifedipine-induced gingival hyperplasia may increase in Japan.
Thus we should consider the mode of chemotherapy and attempt to improve periodontal gingival treatment.

Corresponding author

Register with J-STAGE for free!