Abstract
The effect of azulene gel compound drug (alveolus gel) on experimental gingivitis and periodontitis in rats was investigated. Experimental gingivitis was prepared by irritating the labial gingival tissue in mandible associated with the incisors of a Wistar rat with a bundle of 30 needles. Experimental periodontitis was prepared by injecting collagenase into the same region as above. Three formulations (high, medium, low) of the compound drug were applied on the lesion once a day. Acess® A was used as a positive control. The lesion was examined by naked eye and then extracted and subjected to a histopathological examination and also to an analysis of collagen using Woessner's method. The results are as follows: (1) By naked eye observations, the azulene gel compound drug decreased the bleeding and led to an earlier desquamation of the necrotic lesion. (2) The azulene gel compound drug enhanced collagen formation, two weeks after the formation of the lesion. (3) By the histopathological examination, it was found that the azulene gel compound drug led to decreased inflammation and quickened repair. Thus, azulene gel compound drug might decrease the inflammation of experimental gingivitis and periodontitis and it might also hasten the repair process of the lesion.
