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Volume 8 (1989)
- Issue 3 Pages 209-
- Issue 2 Pages 143-
- Issue 1 Pages 1-
Volume 8, Issue 2
Displaying 1-7 of 7 articles from this issue
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TAKASHI NOJIRI, EISUKE FUJIMOTO, TOSHIHITO BABA, MASAHIRO IWAI, TAKEYO ...1989 Volume 8 Issue 2 Pages 143-149
Published: August 31, 1989
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSFundamental and clinical studies were carried out on CMNX, a new cephamycin antibiotics. The results were as follows:
1) The concentration of this antibiotics in serum, gingiva and jaw bone tissues was measured after an intravenous one shot injection of 1 g of CMNX on a patient. The mean serum, gingiva, and jaw bone tissue concentration were 47.7 μg/ml, 18.5 μg/g, 7.3 μg/g at 1 h, respectively.
2) In vivo antibacterial activity of CMNX was studied on 50 clinical isolates to CMNX. CMNX had a wide spectrum of antibacterial activity against gram-positive and gram-negative bacteria. The MIC80 against aerobes was 12.5 μg/ml, and against anaerobes was 6.3 μg/ml.
3) The clinical efficacy of CMNX was 95% based on committee judgement and 86% based on doctors' judgement.
4) From the above results, it was concluded that CMNX was a useful new antibiotic in the field of oral surgery.View full abstractDownload PDF (721K) -
SUMI KOBAYASHI, YOKO FURUKAWA, AKIRA FUJII, HIROTSUGU YAMAMOTO, TOYOYU ...1989 Volume 8 Issue 2 Pages 150-155
Published: August 31, 1989
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSAcute and subacute toxicities of azulene gel compound drug (alveolus gel), containing cetylpyridinium chloride, azulene, mint oil, and allantoinchlorhydroxyalminium, were investigated to obtain the following results: The LD50 value in the acute toxicity study was 250 times higher than the highest dose formulation of the compound drug, suggesting that the azulene gel compound drug might be used safely. In the subacute toxicity study, body weight, serum biochemistry (S-GOT, S-GPT, glucose, total protein, and blood urine nitrogen), and histopathological findings of the mandibule, esophagus, stomach, duodenum, liver, kidney, and spleen, did not show any significant difference compared to those of the intact control. Thus, the azulene gel compound drug may be applied safely as an external preparations in the oral cavity.View full abstractDownload PDF (2252K) -
SUMI KOBAYASHI, YOKO FURUKAWA, YOSHIAKI KANEKO, SEIMI ISHIHAMA, AKIRA ...1989 Volume 8 Issue 2 Pages 156-162
Published: August 31, 1989
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSThe effect of azulene gel compound drug (alveolus gel) on experimental gingivitis and periodontitis in rats was investigated. Experimental gingivitis was prepared by irritating the labial gingival tissue in mandible associated with the incisors of a Wistar rat with a bundle of 30 needles. Experimental periodontitis was prepared by injecting collagenase into the same region as above. Three formulations (high, medium, low) of the compound drug were applied on the lesion once a day. Acess® A was used as a positive control. The lesion was examined by naked eye and then extracted and subjected to a histopathological examination and also to an analysis of collagen using Woessner's method. The results are as follows: (1) By naked eye observations, the azulene gel compound drug decreased the bleeding and led to an earlier desquamation of the necrotic lesion. (2) The azulene gel compound drug enhanced collagen formation, two weeks after the formation of the lesion. (3) By the histopathological examination, it was found that the azulene gel compound drug led to decreased inflammation and quickened repair. Thus, azulene gel compound drug might decrease the inflammation of experimental gingivitis and periodontitis and it might also hasten the repair process of the lesion.View full abstractDownload PDF (5293K) -
TOSHIMI MUROKI, KIYOMASA NAKAGAWA, ETUHIDE YAMAMOTO1989 Volume 8 Issue 2 Pages 163-175
Published: August 31, 1989
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSThis study was performed to analyze the causative bacteria and pharmacological movement of antibiotics in sinus membrane in odontogenic sinusitis. A total of 257 isolates were obtained; the number of aerobes and anaerobes were 152 (69.1 %) and 105 (40.9%), respectively. Bacterial genera isolation with high frequency were Streptococcus (53 strains) and Staphylococcus (42 strains) in the aerobes, and Veillonella (50 strains) and Peptococcus (21 strains) in anaerobes. In aerobes and anaerobes, all strains except one were susceptible to CER, and more than 90% of the isolates were susceptible to CLDM. The pharmacological movement of ABPC, CER, and CLDM in sinus membrane was investigated in rats and patients with odontogenic maxillary sinusitis by measuring the concentration of the drug by the cup method. These findings suggest that ABPC, CER, CZON and CLDM would be clinically effective for the treatment of odontogenic maxillary sinusitis.View full abstractDownload PDF (1703K) -
TAKASHI YOSHII, YOSHIKI OTSUKA, KANAKO NAKASUJI, SOUICHIROU KOBAYASHI, ...1989 Volume 8 Issue 2 Pages 176-187
Published: August 31, 1989
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSClinicostatistical observation was conducted in 489 cases of oral and maxillofacial injury during the past 3 years. Bacteriological studies were carried out in 18 cases of new injuries. The susceptibilities of isolates from the wound in the oral cavity to ABPC, CFTM, CCL, CDX and CEX were determined. The results were as follows: 1) Infection following oral and maxillofacial injury was found in 12 cases (2.5%) out of 489 cases. Postoperative infection was found in 9 cases (3.9%) out of 231 cases operated on. Streptococcus was isolated from the pus in high frequency and was found in 7 cases out of 9 cases. 2) 55 strains were isolated from the wound of 18 cases. S. sanguis (66.7%), Peptostreptococcus sp. (38.9%) and Neisseria sp. (33.3%) were isolated in high frequency in all of the cases. As a whole, ABPC and CFTM exhibited strong antibacterial activities, but some highly resistant gram negative bacilli were found. CCL, CDX and CEX showed lower activity compared with the other 2 antiviotics.View full abstractDownload PDF (1086K) -
AKIRA MATSUMOTO, YOH HISADA1989 Volume 8 Issue 2 Pages 188-193
Published: August 31, 1989
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSIt was investigated whether or not the ALPase activity and synthesis of chondroitin sulfate, which increase in a low Ca environment, are restored to their normal conditions by the cessation of a low Ca environment.
The femora of a 1-day-old rat of Wistar strain were cultured in low Ca medium. 6 days in culture [35S] sulfate (1μCi/ml) was added to C, M, (BGTb) . They were cultured for a further 2 days after the cessation of a low Ca environment. After the culture, ALPase activity and the degree of incorporation of [35S] sulfate to femora were measured. As a result of that experiment, the acceleration of ALPase activity and chondroitin sulfatesynthesis tended to decrease after the cessation of a low Ca environment.
It was confirmed that ALPase activity and chondroitin sulfate-synthesis was in the cultured long bone accelerated when placed in a low Ca environment.View full abstractDownload PDF (634K) -
KAZUNARI KARAKIDA, TAKASHI IMOTO1989 Volume 8 Issue 2 Pages 194-204
Published: August 31, 1989
Released on J-STAGE: June 08, 2010
JOURNAL FREE ACCESSThe blood concentrations of cefteram were compared by a crossover test in 8 healthy volunteers who were perorally given cefteram pivoxil (CFTM-PI) fasting and after a meal. The results were analysed by pharmacokinetics and moment analysis.
CFTM-PI is advantageous after a meal rather than when fasting, and the administered dosage of 200 mg was superior to the administered dosage of 100 mg.
From the result of pharmacokinetics and moment analysis, it was found that MRT was useful reducing a biological half life as indicated by the results of pharmacokinetics.View full abstractDownload PDF (858K)
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