抄録
The Effect of gargle (TG-89) containing azulene sodium sulfonate and benzethonium chloride, on experimental gingivitis and surgical wound in rats was investigated. Experimental gingivitis was prepared by irritating the labial gingival tissue in mandibular associated with incisors of Wistar rat with a bundle of 30 needles. Surgical wound was made by incising holizontal-vertical lattice by a scalpel in the same region as above. Three formulations (high, medium, low) of the TG-89 were applied on the lesion once a day. Pysiological sailne solution was used as a negative control. Rats with no treatment were considered as an intact control. The lesion was examined by naked eye and then extracted and subjected to a histopathological examination. The results are as follows : (1) By naked eye observation, TG-89 led to decreased bleeding and earlier desquamation of necrotic lesion. (2) By the histopathological examination, it was found that TG-89 led to decrease inflammation and quickened repair. Thus, TG-89 might depress the inflammation of experimental gingivitis and surgical wound and it might also hasten the repair process of the lesion.
