THE RELATIONSHIP BETWEEN THE BREAST-FEEDING AND THE ALLERGIC DISEASE

Abstract

In order to clarify relation of nutrition in infants and allergic diseases, we examined allergic disease frequency and pathogenesis mechanism in the breast-feeding infant.
We performed the questionnaire survey to mother at six month after birth, and confirmed the nourishment method and the allergic diseases. In the result, even if exclusive breast-feeding, there was one case which has shown the symptoms of allergic diseases.
The cytokine and the food antigen in breast-milk were examined. TGF-β1 and 2 existed in a high concentration in breast-milk. In breast-milk, food antigens, such as ovalbumin, casein, and gliadin, were detected. A possibility that the cytokine and the food antigen in breast-milk were related to the antigen sensitization and immune tolerance was suggested. At the case who have allergy diseases in spite of exclusive breast-feeding, a possibility that some proteins in breast-milk were acting on endogenous allergen was also suggested.