Abstract
A five year-old boy presented an urticaria induced by cold from the winter in three year-old. He was brought to our hospital because his symptom was getting worse. The diagnosis as a primary acquired cold urticaria was confirmed by positive cold stimulation test and negative results of secondary cause. The plasma histamine levels in the peripheral blood were sampled before and at 5 and 20 minutes after the cold stimulation test. A significant elevation of histamine was observed. Furthermore, efficacy of anti-histamine agent suggests a pivotal role of histamine in this patient, although involvement of other chemical mediators can not be entirely excluded. Here, we present the case because there have been few reports describing the chemical mediators of cold urticaria in childhood. A further examination is necessary with the accumulation of the pediatric cases.
