Abstract
Human respiratory syncytial virus (RSV), a major respiratory viral pathogen, is an enveloped and negative-strand RNA paramyxovirus. Epidemiologic studies show that lower respiratory tract infections caused by RSV is risk factor for both recurrent wheezing and childhood asthma. The pathogenesis of wheezing diseases post-viral infection would be due to (host) Gene-Virus Interaction. The suppressor of cytokines signaling (SOCS) gene family utilizes a feedback loop to inhibit cytokine responses and block the activation of the JAK/STAT signaling pathway. RSV infection up-regulated SOCS1, SOCS3, and CIS mRNA expression in human laryngeal carcinoma cell line, HEp-2 cell. The pathogenesis of wheezing diseases post-viral infection could be declared by the study of SOCS expression in structural cells, such as endothelial, epithelial, smooth muscle, nerve cells, and inflammatory cells within the lung.
