An instruction to elucidate the causative foods in the patients of food-dependent exercise-induced anaphylaxis with provocation tests

Abstract

Food-dependent exercise-induced anaphylaxis (FEIAn) is a relatively rare disease. However, once the diagnosis of FEIAn and the causative food would be determined, the quality of life (QOL) of the patient must be remarkably improved. For the accurate diagnosis of FEIAn the elimination test of the suspected food from the diet is not sufficient and the applying the provocation test should be desirable in all patients except for the severest cases. However, there was no standardized provocation test. Moreover, the positive rate of the previous method was so low that it was not always easy to elucidate the causative food.
In April 2009 we proposed the standard protocol of the provocation test of FEIAn in the guideline of oral provocation test for food allergy 2009 from the study group of food allergy in Japan Pediatric Allergy Society. We hope that this standard test would contribute to the accurate diagnosis of FEIAn and the improvement of the QOL of the patients.