The factors that modify the development and exacerbation of bronchial asthma

Abstract

By recent birth cohort studies, it has been demonstrated that the most important environmental factors that predispose to the development of asthma are lower respiratory tract viral infections associated with wheezing, especially in early childhood, and repeated inhalation exposure to allergens, which appear to be synergistic. These factors may also influence the exacerbation of asthma. The recent studies that clarify the mechanism of interaction between these factors in the development of asthma have been focused on the role of gene-environmental interaction and epigenetics. Further studies will be needed to clarify the exclusion mechanisms of viruses, especially rhinovirus which lead to damage airway epithelium, from the airway, resulting in preventing the development and exacerbation of asthma.