2017 Volume 31 Issue 1 Pages 28-32
Pediatricians often meet children with virus-induced asthma attacks, and many reports have shown that viruses, such as rhinovirus, respiratory syncytial virus (RSV), may exacerbate asthma attacks.
Severe respiratory issues including pneumonia, atelectasis and severe asthma attack have been reported to occur in hospitalized children with A (H1N1) pdm09 infection. Bronchial asthma increases the risk of hospital admission and intensive care in A (H1N1) pdm09-infected children. The hospitalized children with A (H1N1) pdm09-induced pulmonary complications did not receive long term management for bronchial asthma.
In this study, we report clinical features in the children with A (H1N1) pdm09-induced asthma attacks and cytokine profiles of bronchoalveolar lavage fluids in a mouse model of bronchial asthma during A (H1N1) pdm09. These results suggest that A (H1N1) pdm09 infection can induce more severe pulmonary inflammation in the settings of bronchial asthma than seasonal H1N1 infection, based on the excessive production of inflammatory cytokines and the reciprocal depression of anti-viral cytokines, along with high viral loads in a mouse model of bronchial asthma.
