2017 Volume 31 Issue 1 Pages 53-57
In Japanese Pediatric Guideline for Food Allergy 2016, detailed interview, general blood tests and various allergy tests are useful for diagnosis of food-dependent exercise-induced anaphylaxis (FDEIA). And the exercise-induced oral food challenge is preferable for definitive diagnosis.
However, the reproducibility of the exercise-induced oral food challenge is not always high. Then allergen components have attracted attention as one of new diagnostic tools, and will consider to be useful for diagnosis of FDEIA in recent years.
Allergen components were measured against pediatric wheat-dependent exercise-induced anaphylaxis (WDEIA) and pediatric peach-dependent exercise-induced anaphylaxis experienced in our department. These results suggested that the combination of Tri a 19, Tri a 21, Tri a 26 and Tri a 37, may be useful for diagnosing pediatric WDEIA, unlike adult patterns. In addition, Pru p 7 of pediatric peach FDEIA was useful as well as previously reported for adult peach immediate allergy, and Pru p 3 was also related. Then, Pru p 7 and Pru p 3 may be useful for the diagnosis of pediatric peach FDEIA.
At present, there are few studies on allergen components except for some foods, and detailed examination is required continuously.
