2017 Volume 31 Issue 1 Pages 58-62
Aspirin is known to enhance the both of food allergy and food-dependent, exercise-induced anaphylaxis (FDEIA) symptom in adult cases. But, it is not conclusive in children. The 3-days challenge tests were performed in patients suspected of having FDEIA. The patients were examined with a causal food and exercise on the first day, with aspirin and the causal food on the second day, and with aspirin, the causal food, and exercise on the third day. We defined a positive reaction as the appearance of symptoms or a 180% increase in the plasma histamine level. Finally, after the test pretreated with aspirin before the food and exercise challenge, positive results in response to causal foods were successfully provoked. Positive results were induced by food and exercise challenges in only half patients. In the absence of an exercise challenge, aspirin and food provoked a reaction in only about 10%. Aspirin enhanced the frequency of positive reactions during challenge tests with a causal food and exercise by two-fold. In children, the exercise may be indispensable factor in mechanism of aspirin which enhances food allergy.
