RESEARCH ON LEVELS OF IgG SUBCLASS IN ALLERGIC CHILDREN (THIRD REPORT)

IgG2 AGAINST PNEUMOCOCCAL POLYSACCHARIDE ANTIGEN AND THE AGING

Abstract

We investigated IgG2 against Pneumococcal polysaccharide antigen to know the immune response in IgG2. The subjects were 36 patients aged 4 months to 14 years with allergy and 98 healthy control aged 4 months to 14 years. We carried on ELISA to measure pneumococcal IgG2 antibodies, The polyvarent pneumococcal vaccine was used for the antigen. The mean of pneumococcal IgG2 antibodies in healthy children were 0.735 in below 1 year, 1.66 in 1year, 2.00 in 2 years, 4.09μg/ml in 3 years respectively. The antibodies in each age became higher by aging. The pneumococcal IgG2 antibodies was not correlat ed with the levels of IgG2 in healthy children. The antibodies in allergic patient were normal except one case. It was suggested that most allergic children showed normal responses in IgG2 levels against antigen.