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Volume 11 (1997)
- Issue 4 Pages 243-
- Issue 3 Pages 133-
- Issue 2 Pages 41-
- Issue 1 Pages 1-
Volume 11, Issue 1
Displaying 1-6 of 6 articles from this issue
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COMPARISON OF PLASMA THEOPHYLLINE CONCENTRATION BETWEEN THEOLONG® AND SLO-BID® IN ASTHMATIC CHILDRENShozo Maeda, Sachiyo Suzuki1997 Volume 11 Issue 1 Pages 1-5
Published: March 25, 1997
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSWe have investigated the difference of pharmachokinetics between Theolong® 100mg tablet and Slobid® 100mg capsel dosing at 12-hour intervals comparing in 9 asthmatic children using a cross-over method. Theophylline concentration were measured on 7th day and 14th day at 0, 3, 6, 9 and 12hr after the morning dose of theophyline.
There was no significant difference in the plasma theophylline level of each time. In the case of Theolong®, the mean maximum serum concentration (Cmax) was significantly higher. In the case of Slo-bid®, peak-trough difference was significantly lower. And there were no significant differences in the area under the curve (AUC), the mean minimum serum concentration (Cmin) and the mean time to reach Cmax (Tmax).View full abstractDownload PDF (829K) -
Mani Miyoshi, Takashi Sakurai, Soichi Kodama1997 Volume 11 Issue 1 Pages 6-12
Published: March 25, 1997
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSThe study deals with the physical growth of 133 infants with atopic dermatitis and 18controls. The SD scores of wight and serum IGF-I levels in severe group was significantly lower than those of mild and modelate groups. On the otherhand, the SD scores of weight and serum IGF-I levels showed no significant difference between the patients with and without food elimination. These results suggested that pathogeneses of the impaired physical growth of severe atopic infants may be due to malnutrition because of malabsorption from small intestine, and avoidance of allergenic foods do not disturb the physical growth in severe atopic infants. The SD scores of height in the patients with severe restricted diet, namely, avoidance of strictly not only egg but also cow's milk, was significantly lower than those of in the patients with avoidance of egg or cow's milk. Those results suggested that strict avoidance of many foods shoud not be extended over a long-term.View full abstractDownload PDF (860K) -
IgG2 AGAINST PNEUMOCOCCAL POLYSACCHARIDE ANTIGEN AND THE AGINGHisashi Kawashima, Yasuyo Kashiwagi, Masato Sasamoto, Sachiko Konishi, ...1997 Volume 11 Issue 1 Pages 13-17
Published: March 25, 1997
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSWe investigated IgG2 against Pneumococcal polysaccharide antigen to know the immune response in IgG2. The subjects were 36 patients aged 4 months to 14 years with allergy and 98 healthy control aged 4 months to 14 years. We carried on ELISA to measure pneumococcal IgG2 antibodies, The polyvarent pneumococcal vaccine was used for the antigen. The mean of pneumococcal IgG2 antibodies in healthy children were 0.735 in below 1 year, 1.66 in 1year, 2.00 in 2 years, 4.09μg/ml in 3 years respectively. The antibodies in each age became higher by aging. The pneumococcal IgG2 antibodies was not correlat ed with the levels of IgG2 in healthy children. The antibodies in allergic patient were normal except one case. It was suggested that most allergic children showed normal responses in IgG2 levels against antigen.View full abstractDownload PDF (775K) -
Yuhei Hamasaki, Ikuko Kobayashi, Masafumi Zaitu, Rika Hayasaki, Shuich ...1997 Volume 11 Issue 1 Pages 18-23
Published: March 25, 1997
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSA series of reports for optimal procedures for inhalation technique with beta-2 metered dose inhaler (β2-MDI) were previously published in this journal by a research group for β2-inhalation therapy in children in western Japan. We have surveyed the related issues for inhalation techniques of β2-MDI from special ists for child asthma in all over Japan and general pediatricians in Fukuoa-city and Saga-prefecture. The results demonstrated that (1) 93% of allergy specialists and 82% of general pediatricians prescribed β2 MDI with instructions for use, (2) only 28% of allergy specialists, however, confirmed the procedures by letting patients inhale MDI in front of doctors and (3) not many doctors in both groups instructed the in halation techniques which were recommended as the most optimal procedures by the research group.View full abstractDownload PDF (1173K) -
Sei Sasaki, Masahiko Arita, Takehiko Matsui, Yasuhiro Kabasawa, Yuko G ...1997 Volume 11 Issue 1 Pages 24-32
Published: March 25, 1997
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSThe antigenecity and nutritional adequacy of N-253 formula, a partly hydrolyzed formula, were evaluated in high risk infants with a family history of atopy, on immunological and hematological parameters, weight gain, clinical conditions and stool characteristics; during the first four months of life. Its effects were compared with those observed in infants taking a conventional infant formula and breast-fed infants, There were no changes in serum IgE, cow's milk specific IgG, cow's milk-specific IgG4 concentrations and the number of eosinophils in the N-253 formula-fed infants during the study period. Whereas, those parameters were increased in infants fed with the conventional infant formula and in breast-fed infants. Positive RAST against cow's milk was not detected in the N-253 formula-fed infants (0/33), while it was detected in conventional infant formula-fed infants (2/13). Green and watery stools were observed more frequently in the N-253 formula-fed infants than in the conventional infant formula-fed infants. Weight gain and hematological values were within normal ranges in all three groups during the study period. These results suggest that the antigenecity of cow's milk is reduced in N-253 formula and that N-253 formula has nutritional efficacy for infants.View full abstractDownload PDF (1468K) -
JAPANESE SOCIETYOF PEDIATRIC ALLERGY AND CLINICAL1997 Volume 11 Issue 1 Pages 33-40
Published: March 25, 1997
Released on J-STAGE: April 30, 2010
JOURNAL FREE ACCESSThe causes of life-threatening asthma (LTA) were analyzed on 79 patient from 1989 to October, 1995. Ages ranged 0-27 years old (mean 9.7±6.4 years), consisting of 41 boys and 38 girls. Of 79 patients, comprised 11 cases of mild, 21 cases of moderate, 28 cases of severe asthma, and 19 cases of unknown. The contributory factors to LTA attack were thought to be unexpected sudden exacerbation. A strong dependence on β-stimulant with MDI was observed in 16.5% of the patients, which rate was approximately half as compared with that of asthma death. In thirteen cases, the possible causes of LTA attack were thought to be undertreatment or low compliance. Four cases of 79 patients were oral steroid dependent patients.View full abstractDownload PDF (1382K)
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