Abstract
Sixteen egg-hypersensitive subjects with high IgE antibody titers for egg white and ovomucoid (OM) were divided into two groups of outgrow (n=9) and persistence of egg hypersensitivity (n=7). Egg hypersensitivity was judged based on the results of double-blinded placebo-controlled food challenges with freeze-dried egg white antigens. We measured specific IgE antibodies for ovomucoid (OM) third domains with (D3 CHO) or without carbohydrate (D3) at the time of the first challenge, and compared the titers between the both groups. The subjects with positive results to the follow-up challenge showed significantly higher specific IgE antibodies for D3 and D3CHO than the subjects with negative challenges. The sensitivity, specificity and accuracy for a predictiton of outcome of egg hypersensitivity of specific IgE antibody titers to D3 and D3CHO were 100%, 71.4% and 87.5%, and 88.9%, 71.4% and 81.3%, respectively. These results indicated that specific IgE antibodies for D3 with or without CHO gave a useful diagnostic tool for a predictition of outgrow of hen's egg hypersensitivity.
